Overview

Valerian (Valeriana officinalis) is an herb native to Europe and parts of Asia. Valerian root has a long history of use as a sedative.

Valerian can grow to be just over 6 feet tall and has a strong odor. It seems to act like a sedative in the brain and nervous system. Valerian has been used as a traditional medicine dating back to ancient Greek and Roman times.

People commonly use valerian for sleep disorders, especially insomnia. Valerian is also used for anxiety, stress, and many other conditions, but there is no good scientific evidence to support most of these uses.

Uses & Effectiveness

Possibly Effective for

  • Insomnia. Taking valerian root extract 300-600 mg by mouth daily seems to improve sleep quality. Continuous use for up to 4 weeks might be needed before an effect is noticeable.
There is interest in using valerian for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Valerian is likely safe when used short-term. Valerian has been used safely in doses of 300-600 mg daily for up to 6 weeks. The safety of long-term use is unknown.

Valerian is usually well-tolerated. Some common side effects include dizziness, drowsiness, headache, stomach upset, mental dullness, and vivid dreams. It might cause withdrawal symptoms when discontinued after long-term use. To avoid withdrawal symptoms after long-term use, it's best to reduce the dose slowly over a week or two before stopping completely.

Special Precautions and Warnings

When taken by mouth: Valerian is likely safe when used short-term. Valerian has been used safely in doses of 300-600 mg daily for up to 6 weeks. The safety of long-term use is unknown.

Valerian is usually well-tolerated. Some common side effects include dizziness, drowsiness, headache, stomach upset, mental dullness, and vivid dreams. It might cause withdrawal symptoms when discontinued after long-term use. To avoid withdrawal symptoms after long-term use, it's best to reduce the dose slowly over a week or two before stopping completely.
Pregnancy and breast-feeding: There isn't enough reliable information to know if valerian is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: Valerian is possibly safe for children when taken by mouth appropriately for 4-8 weeks.

Surgery: Valerian slows down the central nervous system. Anesthesia and other medications used during surgery also affect the central nervous system. The combined effects might be harmful. Stop taking valerian at least two weeks before a scheduled surgery.

Interactions

    Moderate Interaction

    Be cautious with this combination

  • Alcohol (Ethanol) interacts with VALERIAN

    Alcohol can cause sleepiness and drowsiness. Valerian might also cause sleepiness and drowsiness. Taking large amounts of valerian along with alcohol might cause too much sleepiness.

  • Alprazolam (Xanax) interacts with VALERIAN

    Valerian might cause sleepiness. Alprazolam also causes sleepiness. Taking valerian along with alprazolam might cause too much sleepiness.

  • Sedative medications (CNS depressants) interacts with VALERIAN

    Valerian might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking valerian with sedative medications might cause breathing problems and/or too much sleepiness.

  • Medications changed by the liver (Glucuronidated drugs) interacts with VALERIAN

    Some medications are changed and broken down by the liver. Valerian might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

    Minor Interaction

    Be watchful with this combination

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with VALERIAN

    Some medications are changed and broken down by the liver. Valerian might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with VALERIAN

    Some medications are changed and broken down by the liver. Valerian might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Dosing

Valerian has most often been used by adults in doses of 300-600 mg by mouth daily for up to 6 weeks. It's commonly used in combination products that contain other sedative herbs, such as hops, passion flower, and lemon balm. Using valerian long-term might cause dependence. Stopping valerian after long-term use might cause withdrawal symptoms. Speak with a healthcare provider to find out what dose might be best for a specific condition.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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