SERRAPEPTASE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Serrapeptase (Serratia peptidase) is a chemical taken from the silkworm. It is a commonly used drug in Japan and Europe made by Takeda Chemical Industries.

Serrapeptase is an enzyme. It helps the body break down protein and might help reduce swelling and mucous. In the US, serrapeptase is used as a dietary supplement.

People use serrapeptase for asthma, back pain, osteoarthritis, swelling after surgery, rheumatoid arthritis, and many other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness

We currently have no information for SERRAPEPTASE overview.

Side Effects

When taken by mouth: Serrapeptase is possibly safe when used for up to 4 weeks. There isn't enough reliable information to know if serrapeptase is safe when used longer-term. It seems to be well-tolerated. Side effects might include stomach upset and nausea.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if serrapeptase is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Serrapeptase might interfere with blood clotting. This might make bleeding disorders worse. If you have a bleeding disorder, check with your healthcare provider before using serrapeptase.

Surgery: Serrapeptase might interfere with blood clotting. This might increase the risk of bleeding during and after surgery. Stop using serrapeptase at least 2 weeks before a scheduled surgery.

Interactions

Moderate Interaction

Be cautious with this combination

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with SERRAPEPTASE
Serrapeptase might slow blood clotting. Taking serrapeptase along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Dosing

Serrapeptase has most often been used by adults at a dose of 30 mg by mouth daily. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157. View abstract.

Kim, J. R., Oh, D. R., Cha, M. H., Pyo, B. S., Rhee, J. H., Choy, H. E., Oh, W. K., and Kim, Y. R. Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. J Microbiol. 2008;46(6):737-743. View abstract.

Kimura, Y., Okuda, H., and Kubo, M. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. J Ethnopharmacol. 1995;45(2):131-139. View abstract.

Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150. View abstract.

Lee, J. E. and Safe, S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochem.Pharmacol. 10-15-2001;62(8):1113-1124. View abstract.

Lim, B. O., Lee, J. H., Ko, N. Y., Mun, S. H., Kim, J. W., Kim, do K., Kim, J. D., Kim, B. K., Kim, H. S., Her, E., Lee, H. Y., and Choi, W. S. Polygoni cuspidati radix inhibits the activation of Syk kinase in mast cells for antiallergic activity. Exp.Biol.Med (Maywood.) 2007;232(11):1425-1431. View abstract.

Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. View abstract.

Krishna BP, Reddy BP, Yashavanth Kumar DS, Ummar M, Shekhar V, Chandra Tiwari RV. Role of Serratiopeptidase and Dexamethasone in the Control of Postoperative Swelling. Ann Maxillofac Surg 2020;10(1):108-113. View abstract.

Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. View abstract.

Nakamura S, Hashimoto Y, Mikami M, et al. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology 2003;8:316-20.. View abstract.

Shimizu H, Ueda M, Takai T, et al. A case of serratiopeptidase-induced subepidermal bullous dermatosis. J Int Med Res 1990;18:379-88.. View abstract.

Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30.. View abstract.

Tamimi Z, Al Habashneh R, Hamad I, Al-Ghazawi M, Roqa'a AA, Kharashgeh H. Efficacy of serratiopeptidase after impacted third molar surgery: a randomized controlled clinical trial. BMC Oral Health 2021;21(1):91. View abstract.

Tharani Kumar S, Ashok Prasanna R, Kirubanandan JR, Elaveyini U, Prasanna Devi S, Balasubramaniam M. Postoperative Healing after Surgical Removal of Mandibular Third Molar: A Comparative Study between Two Proteolytic Enzymes. J Pharm Bioallied Sci 2020;12(Suppl 1):S289-S294. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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SERRAPEPTASE - Uses, Side Effects, and More