Yang G, Zhang L, Fan L. [Anti-angina effect of puerarin and its effect on plasma thromboxane A2 and prostacyclin]. Zhong Xi Yi Jie He Za Zhi 1990;10:82-4,68. View abstract.
Ye HY, Qiu F, Zeng J, et al. [Effect of daidzein on antiarrhythmia]. Zhongguo Zhong Yao Za Zhi 2003;28:853-6. View abstract.
Yeh, T. S., Chan, K. H., Hsu, M. C., and Liu, J. F. Supplementation with soybean peptides, taurine, Pueraria isoflavone, and ginseng saponin complex improves endurance exercise capacity in humans. J Med Food 2011;14(3):219-225. View abstract.
Yu Z, Zhang G, Zhao H. [Effects of Puerariae isoflavone on blood viscosity, thrombosis and platelet function]. Zhong Yao Cai 1997;20:468-9. View abstract.
Zhang Y, Chen J, Zhang C, et al. Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography.J Steroid Biochem Mol Biol 2005;94:375-81. View abstract.
Zhao Z, Yang X, Zhang Y. [Clinical study of puerarin in treatment of patients with unstable angina]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1998;18:282-4. View abstract.
Zheng G, Zhang X, Zheng J, et al. [Hypocholesterolemic effect of total isoflavones from Pueraria lobata in ovariectomized rats]. Zhong Yao Cai 2002;25:273-5. View abstract.
Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246. View abstract.
Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9. View abstract.
Coulibaly O, Thera MA, Koné AK, et al. A double-blind randomized placebo-controlled clinical trial of squalamine ointment for tinea capitis treatment. Mycopathologia. 2015;179(3-4):187-93. View abstract.
Garcia CA, Quiroz-Mercado H, Uwaydat S, et al. A phase I/II trial of intravenous squalamine lactate for treatment of choroidal neovascularization in age related macular degeneration (ARMD). Invest. Ophthal. Visual Sci. 2004;45(13):2362.
Herbst RS, Hammond LA, Carbone DP, et al. A phase I/IIA trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Clin Cancer Res. 2003;9(11):4108-15. View abstract.
Kikuchi K, Bernard EM, Sadownik A, et al. Antimicrobial activities of squalamine mimics. Antimicrob Agents Chemother 1997;41:1433-8. View abstract.
Magainin Pharmaceuticals announces new research program for anti-angiogenesis agent - Squalamine - at Georgetown Univ Med Ctr. PRNewswire. www.prnewswire.com (Accessed 22 January 2000).
Magainin Presents Neuroblastoma Data for Squalamine at AACR Meeting. Available at: www.prnewswire.com (Accessed 3 April 2000).
Moore KS, Wehrli S, Roder H, et al. Squalamine: an aminosterol antibiotic from the shark. Proc Natl Acad Sci U S A 1993;90:1354-8. View abstract.
Rose V, Schiller J, Wood A, et al. Randomized phase II trial of weekly squalamine, carboplatin, and paclitaxel as first line therapy for advanced non-small cell lung cancer. J. Clin. Oncol. 2004;22(14 suppl):7109.
Sills AK Jr, Williams JI, Tyler BM, et al. Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature. Cancer Res 1998;58:2784-92. View abstract.
Buckle J. Use of aromatherapy as a complementary treatment for chronic pain. Altern Ther Health Med 1999;5:42-51. View abstract.
Eddouks M, Lemhardri A, Zeggwagh NA, Michel JB. Potent hypoglycaemic activity of the aqueous extract of Chamaemelum nobile in normal and streptozoticin-induced diabetic rats. Diabetes Res Clin Pract 2005;67(3);189-95.
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Guimaraes R, Barros L, Duenas M, et al. Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations. Food Chem 2013;136(2):718-25. View abstract.
Lopez Jornet P, Aznar-Cayuela C. Efficacy of topical chamomile management vs. placebo in patients with oral lichen planus: a randomized double-blind study. J Eur Acad Dermatol Venereol 2016;30(10):1783-6. View abstract.
Mostafapour Kandelous H, Salimi M, Khori V, Rastkari N, Amanzadeh A, Salimi M. Mitochondrial apoptosis induced by Chamaemelum nobile extract in breast cancer cells. Iran J Pharm Res 2016;15(Suppl):197-204. View abstract.
Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. View abstract.
Shim MS, Je NJ, Lee DY. Aromatherapy Massage for Relief of Pruritus and Stress in Older Women. Altern Ther Health Med 2023;29(2):36-41. View abstract.
Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. View abstract.
Zeggwagh NA, Michel JB, Eddouks M. Vascular effects of aqueous extract of Chamaemelum nobile: in vitro pharmacological studies in rats. Clin Exp Hypertens 2013;35(3):200-6. View abstract.
Belcaro G, Laurora G, Cesarone MR, and et al. Efficacy of Centellase (R) in the treatment of venous hypertension evaluated by a combined microcirculatory model. Curr Ther Res 1989;46(6):1015-1026.
Belcaro GV, Grimaldi R, Guidi G, and et al. Treatment of diabetic micorangiopathy with TTFCA. A microcirculatory study with laser-Doppler flowmetry, P02/PC02, and capillary permeability measurements. Curr Ther Res 1990;47(3):421-428.
Belcaro, G. V., Grimaldi, R., and Guidi, G. Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA. Angiology 1990;41(7):533-540. View abstract.
Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436. View abstract.
Bonte, F., Dumas, M., Chaudagne, C., and Meybeck, A. Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. Planta Med 1994;60(2):133-135. View abstract.
Bradwejn J, Koszycki D, Shlik J, and et al. Centella asiatica decreases the acoustic startle response. 152nd Annual Meeting of the American Psychiatric Association, Washington DC, USA (May 15-20) 1999;
Bradwejn J, Zhou Y, Koszycki, and et al. Effect of acute administration of Gotu-kola (Centella asiatica) on acoustic startle response in healthy volunteers. XXIst Collegium Internationale Neuro-psychopharmacologicum, Glascow, Scotland (July 12-16) 1998;(Abstract Ref: NRW001)
Carlson, J. J., Farquhar, J. W., DiNucci, E., Ausserer, L., Zehnder, J., Miller, D., Berra, K., Hagerty, L., and Haskell, W. L. Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. J Am Diet.Assoc 2007;107(3):422-432. View abstract.
Cesarone MR, Belcaro G, De Sanctis MT, and et al. Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial. Angiology 2001;52(10 suppl 2):S15-S18.
Cesarone MR, Belcaro G, Rulo A, and et al. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPo2-co2, and leg volumetry. Angiology 2001;52(10 suppl 2):S45-S48.
Cesarone MR, Incandela L, De Sanctis MT, and et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52(10 suppl 2):S49-S54.
Cesarone, M. R., Laurora, G., De Sanctis, M. T., Incandela, L., Grimaldi, R., Marelli, C., and Belcaro, G. [The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]. Minerva Cardioangiol. 1994;42(6):299-304. View abstract.
Chatterjee, T. K., Chakraborty, A., Pathak, M., and Sengupta, G. C. Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats. Indian J.Exp.Biol. 1992;30(10):889-891. View abstract.
Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201. View abstract.
Darnis, F., Orcel, L., Saint-Maur, P. P., and Mamou, P. [Use of a titrated extract of Centella asiatica in chronic hepatic disorders (author's transl)]. Sem.Hop. 11-8-1979;55(37-38):1749-1750. View abstract.
De Sanctis MT, Belcaro G, Incandela L, and et al. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: A clinical, prospective, placebo-controlled, randomized, dose-ranging trial. Angiology 2001;52(10 suppl 2):S55-S59.
De Sanctis MT, Incandela L, Cesarone MR, and et al. Acute effects of TTFCA on capillary filtration in severe venous hypertension. Panminerva Medica 1994;36(2):87-90.
DeLucia R, Sertie JAA, Camargo EA, and et al. Pharmacologic and toxicological studies on Centella asiatica extract. Fitoterapia 1997;68:413-416.
Grimaldi, R., De Ponti, F., D'Angelo, L., Caravaggi, M., Guidi, G., Lecchini, S., Frigo, G. M., and Crema, A. Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid. J Ethnopharmacol. 1990;28(2):235-241. View abstract.
Incandela L, Belacaro G, Cesarone MR, and et al. Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized study. Angiology 2001;52(10 suppl 2):S27-S31.
Incandela L, Belcaro G, De Sanctis MT, and et al. Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model. Angiology 2001;52(10 suppl 2):S61-S67.
Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193. View abstract.
Kaziulin, A. N., Petukhov, A. B., and Kucheriavyi, IuA. [Efficiency of includes of bioactive substances in diet of patient with hepatic encephalopathy]. Vopr.Pitan. 2006;75(2):40-44. View abstract.
Klovekorn, W., Tepe, A., and Danesch, U. A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis. Int.J.Clin.Pharmacol.Ther. 2007;45(11):583-591. View abstract.
Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207. View abstract.
Ming, Z. J., Liu, S. Z., and Cao, L. [Effect of total glucosides of Centella asiatica on antagonizing liver fibrosis induced by dimethylnitrosamine in rats]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(8):731-734. View abstract.
O'Brien, B. Night eating syndrome and Gotu Kola. Ir.Med J 2005;98(10):250-251. View abstract.
O'Keeffe, P. A trial of asiaticoside on skin graft donor areas. Br J Plast.Surg 1974;27(2):194-195. View abstract.
Ramanathan, M., Sivakumar, S., Anandvijayakumar, P. R., Saravanababu, C., and Pandian, P. R. Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats. Indian J Exp Biol 2007;45(5):425-431. View abstract.
Rush, W. R., Murray, G. R., and Graham, D. J. The comparative steady-state bioavailability of the active ingredients of Madecassol. Eur J Drug Metab Pharmacokinet. 1993;18(4):323-326. View abstract.
Sairam, K., Rao, C. V., and Goel, R. K. Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats. Indian J.Exp.Biol. 2001;39(2):137-142. View abstract.
Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. View abstract.
Sarma DNK, Khosa RL, Chansauria JPN, and et al. Antistress activity of Tinospora cordifolia and Centella asiatica extracts. Phytotherapy Research 1996;10(2):181-189.
Sasaki, S., Shinkai, H., Akashi, Y., and Kishihara, Y. Studies on the mechanism of action of asiaticoside (Madecassol) on experimental granulation tissue and cultured fibroblasts and its clinical application in systemic scleroderma. Acta Derm.Venereol. 1972;52(2):141-150. View abstract.
Shukla, A., Rasik, A. M., and Dhawan, B. N. Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother.Res 1999;13(1):50-54. View abstract.
Suguna, L., Sivakumar, P., and Chandrakasan, G. Effects of Centella asiatica extract on dermal wound healing in rats. Indian J Exp Biol 1996;34(12):1208-1211. View abstract.
Sunilkumar, Parameshwaraiah, S., and Shivakumar, H. G. Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats. Indian J Exp Biol. 1998;36(6):569-572. View abstract.
Tenni, R., Zanaboni, G., De Agostini, M. P., Rossi, A., Bendotti, C., and Cetta, G. Effect of the triterpenoid fraction of Centella asiatica on macromolecules of the connective matrix in human skin fibroblast cultures. Ital.J Biochem 1988;37(2):69-77. View abstract.
Velasco, M. and Romero, E. Drug interaction between asiaticoside and some anti-inflammatory drugs in wound healing of the rat. Curr Ther Res Clin Exp 1976;19(1):121-125. View abstract.
Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. View abstract.
Vogel HG, DeSouza N, and D'Sa A. Effects of terpenoids isolated from Centella asiatica on granuloma tissue. Acta Therapeutica 1990;16:285-298.
Yoosook, C., Bunyapraphatsara, N., Boonyakiat, Y., and Kantasuk, C. Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine. 2000;6(6):411-419. View abstract.
Zheng, M. S. An experimental study of the anti-HSV-II action of 500 herbal drugs. J Tradit.Chin Med 1989;9(2):113-116. View abstract.
Anggraeni S, Umborowati MA, Damayanti D, Endaryanto A, Prakoeswa CRS. Role of Centella asiatica and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers. J Basic Clin Physiol Pharmacol 2021;32(4):589-93. View abstract.
Astutik FEF, Fauzia Zuhroh D, Rizqi Lazuardi Ramadhan M. The effect of gotu kola (Centella asiatica L.) tea on blood pressure of hypertension. Enferm Clin. 2021;31 Suppl 2:S195-S198. View abstract.
Babu TD, Kuttan G, Padikkala J. Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban. J Ethnopharmacol 1995;48:53-7. View abstract.
Balevi M, Balevi A. The effect of Centella Asiatica cream on scar development in patients who underwent open carpal tunnel release surgery. J Hand Ther 2023. View abstract.
Belcaro G, Dugall M, Ippolito E, et al. Pycnogenol and centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events. Minerva Cardioangiol. 2017 Feb;65(1):24-31. View abstract.
Belcaro GV, Rulo A, Grimaldi R. Capillary filtration and ankle edema in patients with venous hypertension treated with TTFCA. Angiology 1990;41:12-8.. View abstract.
Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
Bosse JP, Papillon J, Frenette G, et al. Clinical study of a new antikeloid agent. Ann Plast Surg 1979;3:13,21. View abstract.
Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. View abstract.
Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48. View abstract.
Cesarone MR, Belcaro G, De Sanctis MT, et al. Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial. Angiology 2001;52 Suppl 2:S15-18. View abstract.
Cesarone MR, Belcaro G, Nicolaides AN, et al. Increase in echogenicity of echolucent carotid plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled, randomized trial. Angiology 2001;52 Suppl 2:S19-25. View abstract.
Cesarone MR, Belcaro G, Rulo A, et al. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry. Angiology 2001;52 Suppl 2:S45-8. View abstract.
Cesarone MR, Hu S, Belcaro G, et al. Pycnogenol®-Centellicum® supplementation improves lung fibrosis and post-COVID-19 lung healing. Minerva Med 2022;113(1):135-140. View abstract.
Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2:S49-54. View abstract.
Cesarone MR, Incandela L, De Sanctis MT, et al. Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica. Angiology 2001;52 Suppl 2:S33-7. View abstract.
Chandrika UG, Prasad kumarab PA. Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits. Adv Food Nutr Res. 2015;76:125-57. View abstract.
Cheng CL, Koo MWL. Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Life Sci 2000;67:2647-53. View abstract.
Chiaretti M, Fegatelli DA, Ceccarelli G, Carru GA, Pappalardo G, Chiaretti AI. Comparison of flavonoids and Centella asiatica for the treatment of chronic anal fissure. A randomized clinical trial. Ann Ital Chir. 2018;89:330-336. View abstract.
Chiaretti M, Fegatelli DA, Pappalardo G, Venti MDS, Chiaretti AI. Comparison of Centella with flavonoids for treatment of symptoms in hemorrhoidal disease and after surgical intervention: A Randomized Clinical Trial. Sci Rep. 2020;10(1):8009. View abstract.
Chong NJ, Azziz Z. A systematic review on the chemical constituents of Centella asiatica. Res J Pharma Biol Chem Sci. 2011;2(3):445-459.
Cotellese R, Hu S, Belcaro G, et al. Centella asiatica (Centellicum) facilitates the regular healing of surgical scars in subjects at high risk of keloids. Minerva Chir. 2018;73(2):151-156.
Damkerngsuntorn W, Rerknimitr P, Panchaprateep R, et al. The effects of a standardized extract of Centella asiatica on postlaser resurfacing wound healing on the face: A split-face, double-blind, randomized, placebo-controlled trial. J Altern Complement Med. 2020;26(6):529-536. View abstract.
Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. View abstract.
De Sanctis MT, Belcaro G, Incandela L, et al. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial. Angiology 2001;52 Suppl 2:S55-9. View abstract.
Dutta T, Basu UP. Crude extract of Centella asiatica and products derived from its glycosides as oral antifertility agents. Indian J Exp Biol 1968;6:181-2.
Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. View abstract.
Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. View abstract.
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